Effects of indomethacin and polyunsaturated phosphatidylcholine on short-term control of renal water excretion.
نویسندگان
چکیده
atheroscierosis: the modification of the cholesterol granuloma by phospholipid
منابع مشابه
Effects of prostaglandin synthesis inhibitors on the renin-angiotensin system and renal function.
Equal doses (8 mg/kg) of the nonsteroidal antiinflammatory drugs indomethacin, naproxen, and sulindac and a large dose of sulindac (32 mg/kg) were administered intragastrically to conscious rats after a normal sodium diet, furosemide stimulation, and a low sodium diet for 8 days. Indomethacin, naproxen, and the high dose sulindac (32 mg/kg) decreased urinary prostaglandin E2 excretion significa...
متن کاملIndomethacin Reduces Glomerular and Tubular Damage Markers but Not Renal Inflammation in Chronic Kidney Disease Patients: A Post-Hoc Analysis
Under specific conditions non-steroidal anti-inflammatory drugs (NSAIDs) may be used to lower therapy-resistant proteinuria. The potentially beneficial anti-proteinuric, tubulo-protective, and anti-inflammatory effects of NSAIDs may be offset by an increased risk of (renal) side effects. We investigated the effect of indomethacin on urinary markers of glomerular and tubular damage and renal inf...
متن کاملThe actions of bradykinin and eledoisin in the canine isolated kidney: relationships to prostaglandins.
1. The effects of two vasodilator polypeptides, bradykinin and eledoisin, were studied in isolated blood-perfused canine kidneys before and after administration of indomethacin, an inhibitor of prostaglandin synthesis, Bradykinin, but not eledoisin, releases renal prostaglandins. 2. Before administration of indomethacin, bradykinin decreased urinary osmolality and increased free qater clearance...
متن کاملNon-steroidal anti-inflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone.
Nabumetone, a newer non-steroidal anti-inflammatory drug (NSAID) which preferentially blocks cyclo-oxygenase-2 activity, may be less nephrotoxic than indomethacin. This study tested whether nabumetone has effects different from those of indomethacin on exercise-induced changes in renal function and the renin-aldosterone system. In a randomized fashion, ten subjects were studied after indomethac...
متن کاملEvaluating the effect of short ischemic periods on subsequent rat renal ischemic injury
Introduction: Using brief episodes of ischemia and reperfusion (IR) prior to a more sustained IR insult – ischemic preconditioning (IPC) – can reduce IR injury of the heart, brain and many other tissues. The purpose of present study was to investigate the effect of 2min ischemic periods on subsequent rat renal IR injury. Methods: Male rat's renal IR injury was investigated in a right nephrectom...
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عنوان ژورنال:
- Advances in prostaglandin, thromboxane, and leukotriene research
دوره 13 شماره
صفحات -
تاریخ انتشار 1985